Intracellular Traffic and Neurodegenerative Disorders (Research and Perspectives in Alzheimer’s Disease)
By addebook • Feb 10th, 2009 • Category: Medicine
Intracellular Traffic and Neurodegenerative Disorders (Research and Perspectives in Alzheimer’s Disease)
by: Peter H. St.George-Hyslop, William C. Mobley, Yves Christen
Intracellular Traffic and Neurodegenerative Disorders (Research and Perspectives in Alzheimer’s Disease)
By Peter H. St.George-Hyslop, William C. Mobley, Yves Christen
Publisher: Springer
Number Of Pages: 184
Publication Date: 2008-12-18
ISBN-10 / ASIN: 3540879404
ISBN-13 / EAN: 9783540879404
Product Description:
This book explores the role of sub-cellular trafficking in the pathogenesis, treatment and prevention of neurodegenerative diseases. Recent findings point to faulty trafficking as contributing to the dysfunction and degeneration of neurons and neural circuits. Increasingly, research is targeting the mechanisms responsible and means to address them therapeutically. This book investigates the ways in which sub-cellular trafficking pathways play a role both in the pathological accumulation of these misfolded proteins and in attempts to clear them. Because subcellular protein trafficking has an important role in the biology of neuronal function and survival, this also addresses how trophic factors maintain cell: cell interactions and how the underlying mechanisms may be compromised in neurodegenerative diseases. Examples where the use of such trophic factors may provide a way to modify neurodegenerative diseases are investigated.
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