Ligand Design for G Protein-coupled Receptors (Methods and Principles in Medicinal Chemistry)

By addebook • Jul 15th, 2008 • Category: Pharmacy •

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Ligand Design for G Protein-coupled Receptors (Methods and Principles in Medicinal Chemistry)

Ligand Design for G Protein-coupled Receptors (Methods and Principles in Medicinal Chemistry)
By Didier Rognan, Raimund Mannhold, Hugo Kubinyi, Gerd Folkers

Publisher: Wiley-VCH
Number Of Pages: 284
Publication Date: 2006-03-31
ISBN-10 / ASIN: 3527312846
ISBN-13 / EAN: 9783527312849
Binding: Hardcover

G protein-coupled receptors (GPCRs) are one of the most important target classes in pharmacology and are the target of many blockbuster drugs. Yet only with the recent elucidation of the rhodopsin structure have these receptors become amenable to a rational drug design.

Based on recent examples from academia and the pharmaceutical industry, this book demonstrates how to apply the whole range of bioinformatics, chemoinformatics and molecular modeling tools to the rational design of novel drugs targeting GPCRs.

Essential reading for medicinal chemists and drug designers working with this largest class of drug targets in the human genome.

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