Issues in Risk Assessment
By addebook • Sep 8th, 2008 • Category: Medicine •
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Issues in Risk Assessment
Issues in Risk Assessment
By Committee on Risk Assessment Methodology, National Research Council
Publisher: National Academies Press
Number Of Pages: 374
Publication Date: 1993-01-01
ISBN-10 / ASIN: 0309047862
ISBN-13 / EAN: 9780309047869
Binding: Paperback
The scientific basis, inference assumptions, regulatory uses, and research needs in risk assessment are considered in this two-part volume.
The first part, Use of Maximum Tolerated Dose in Animal Bioassays for Carcinogenicity, focuses on whether the maximum tolerated dose should continue to be used in carcinogenesis bioassays. The committee considers several options for modifying current bioassay procedures.
The second part, Two-Stage Models of Carcinogenesis, stems from efforts to identify improved means of cancer risk assessment that have resulted in the development of a mathematical dose-response model based on a paradigm for the biologic phenomena thought to be associated with carcinogenesis.
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