Immunology and Evolution of Infectious Disease
By addebook • Jul 14th, 2008 • Category: Medicine •
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Immunology and Evolution of Infectious Disease
Immunology and Evolution of Infectious Disease
By Steven A. Frank
Publisher: Princeton University Press
Number Of Pages: 352
Publication Date: 2002-07-01
ISBN-10 / ASIN: 0691095957
ISBN-13 / EAN: 9780691095950
Binding: Paperback
From HIV to influenza, the battle between infectious agents and the immune system is at the heart of disease. Knowledge of how and why parasites vary to escape recognition by the immune system is central to vaccine design, the control of epidemics, and our fundamental understanding of parasite ecology and evolution. As the first comprehensive synthesis of parasite variation at the molecular, population, and evolutionary levels, this book is essential reading for students and researchers throughout biology and biomedicine.
The author uses an evolutionary perspective to meld the terms and findings of molecular biology, immunology, pathogen biology, and population dynamics. This multidisciplinary approach offers newcomers a readable introduction while giving specialists an invaluable guide to allied subjects. Every aspect of the immune response is presented in the functional context of parasite recognition and defense–an emphasis that gives structure to a tremendous amount of data and brings into sharp focus the great complexity of immunology. The problems that end each chapter set the challenge for future research, and the text includes extensive discussion of HIV, influenza, foot-and-mouth disease, and many other pathogens.
This is the only book that treats in an integrated way all factors affecting variation in infectious disease. It is a superb teaching tool and a rich source of ideas for new and experienced researchers. For molecular biologists, immunologists, and evolutionary biologists, this book provides new insight into infectious agents, immunity, and the evolution of infectious disease.
Summary: Excellent
Rating: 5
I really like this book. It presents a wonderfully concise set of well written examples, with key literature cites. Some very interesting problems that illuminate the complexity.
Minor erratum on page 117. States that sum of squares of the two alleles is the incidence of the combined. Correctly, when squaring both sides it is:
(p q)^2 = 1^2
p^2 2pq q^2 = 1
2pq = 1- p^2 - q^2
pq = (1 - p^2 - q^2)/2
So properly speaking, it is one-half of 1 - sum of the 2 squares for the simple case of 2 alleles. i.e. about 27%
But, that is a minor technical error that is common to make. The book is very good and does an excellent job of bridging the gap between introductory material and advanced research questions.
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