Handbook of Molecular-Genetic Techniques for Brain and Behavior Research (Techniques in the Behavioral and Neural Sciences)
By addebook • Oct 3rd, 2008 • Category: Biology •
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Handbook of Molecular-Genetic Techniques for Brain and Behavior Research (Techniques in the Behavioral and Neural Sciences)
Handbook of Molecular-Genetic Techniques for Brain and Behavior Research (Techniques in the Behavioral and Neural Sciences)
By W.E. Crusio, R.T. Gerlai
Publisher: Elsevier Science
Number Of Pages: 994
Publication Date: 1999-10-01
ISBN-10 / ASIN: 0444502394
ISBN-13 / EAN: 9780444502391
Binding: Hardcover
The book gives a broad overview of recombinant DNA techniques for the behavioral neuroscientist, with illustrative examples of applications. Species covered include rodents (mainly mice), Drosophila melanogaster, Caenorhabditis elegans and Danio rerio. Experimental techniques required to characterize the behavioral phenotypes of mutant animals is provided. Several aspects of novel molecular-genetic techniques are overviewed and possible research strategies are explained. The sections of the book start with general descriptions of techniques followed by illustrative examples.
It is divided into six sections. Section 1, bioinformatics and genomics research. Section 2, top-down strategies, where the researcher starts with the phenotype and then analyzes the associated genes; bottom-up strategies, where the physiological chain leading to a phenotype is analyzed starting from the gene product. Section 3, transgenic approaches in rodents including overexpressing foreign genes and gene-targeting; systemic manipulation approaches directly targeting the central nervous system and methods used with invertebrates. Section 4, methods used to evaluate relevant behavioral phenotypes, including learning and aggression. Section 5, examples on molecular brain research in man. Section 6, ethical aspects of research in this field.
Summary: A must have!
Rating: 5
This book is a must have for everyone interested in behavioral and neural genetics. It’s a treasure trove of information, that you will be hard pressed to find in one place together elsewhere. It’s 4 years old by now, but far from out of date. I particularly liked the chapters dealing with behavioral testing, which will remain pertinent for years to come. Recommended for students and experienced researchers alike.
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